epidermal growth factor receptor genes การใช้

• Other significant components of Varmus's scientific work over the past four and a half decades include descriptions of the mechanisms by which retroviral DNA is synthesized and integrated into chromosomes; discovery of the Wnt-1 proto-oncogene with Roel Nusse; elucidation of aspects of the replication cycle of hepatitis B virus ( with Donald Ganem ); discovery of ribosomal frameshifting to make retroviral proteins ( with Tyler Jacks ); isolation of a cellular receptor for avian retroviruses ( with John Young and Paul Bates ); characterization of mutations of the epidermal growth factor receptor gene in human lung cancers, including a common mutation that confers drug resistance ( with William Pao ); and generation of numerous mouse models of human cancer.